Reading this thread on TMI but the constipation hits close to home. Night shift nurse — I started at 299 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 74 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about TMI but the — take the leap. It was the best health decision I have ever made. ❤️

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Relevant to TMI but the constipation is — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 231 → 101 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Thank you Dr.Martinez! This is incredibly helpful. Bookmarking for later. 🙏

+1 to SleepDoc_PDX. Especially the point about "TMI but the constipation is exactly what..." — I have seen the same in my own experience with TMI but the constipation.