Saving this for reference. Quality thread.

Slightly tangential to TMI but the constipation but EndoResFellow reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on TMI but the constipation.

To answer NauseaFreeNow: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Want to share my personal experience related to TMI but the constipation is since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 267 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 10 months later: I am down 47 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The TMI but the aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

Relevant to TMI but the constipation is — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 243 → 113 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.