Zone 2 cardio + GLP-1: synergistic metabolic benefits — need advice — Page 2 | Exercise & Body Composition

PeptideChemSF

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Jan 2024

San Francisco, CA

Jul 17, 2025 at 4:49 PM#6

Dr.RenalNash said:
Short answer: it depends on your starting point

Gonna push back on this one. Zone 2 cardio + GLP-1 synergistic is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But cost accessibility is a real barrier. We should be honest about that.

Last edited: Jul 17, 2025 at 8:49 PM

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Dr.PathRoch

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Jun 2024

Rochester, MN

Jul 17, 2025 at 5:06 PM#7

Adding my data to this Zone 2 cardio + GLP-1 discussion:

Metric	Baseline	Month 3	Month 6
Weight	260 lbs	245 lbs	195 lbs
A1C	6.4%	5.8%	5.2%
hsCRP	4.0	2.0	1.0

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

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TomTeleRx

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Feb 2025

Delaware

Jul 17, 2025 at 5:23 PM#8

sarah_TO — wow. This community is amazing.

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SallyK_inj

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Jul 2024

Iowa

Jul 17, 2025 at 5:40 PM#9

Slightly tangential to Zone 2 cardio + GLP-1 but jim_asheville reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

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