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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseHas anyone dealt with de novo lipogenesis reduction on glp-1? Page 4

Has anyone dealt with de novo lipogenesis reduction on glp-1?

NurseLeah_Nash Sat, Aug 23, 2025 at 1:33 AM 34 replies 1,698 viewsPage 4 of 7
NurseLeah_Nash
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Sep 2024
Nashville, TN
Aug 23, 2025 at 7:13 AM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Has anyone dealt with de.

To answer PharmacoVig_BOS: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

29 8RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 26 others
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dave_SLC
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1,567
Aug 2024
Salt Lake City, UT
Aug 23, 2025 at 7:30 AM#17

Relevant to Has anyone dealt with de novo — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

16 7NicoleRaleigh, james_edin, FranDenver and 13 others
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SaraMom3
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Aug 2024
Ohio
Aug 23, 2025 at 7:47 AM#18

100%. My provider said the same thing about Has anyone dealt.

40 4KetoKyle, CanadaChris, ZaraB_AL and 37 others
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Dr.NutriCornell
Senior Member
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Mar 2024
Ithaca, NY
Aug 23, 2025 at 8:04 AM#19

Slightly tangential to Has anyone dealt with de but WendyG_ATL reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

47 6JenMemphis, pat_auckland, Dr.GastroMayo and 44 others
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anna.melb_AU
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Apr 2024
Melbourne, AU
Aug 23, 2025 at 8:21 AM#20
NurseLeah_Nash said:
Thank you all for the thoughtful replies on Has anyone dealt with de

This is exactly right. NurseLeah_Nash articulated what I have been trying to explain to my doctor for months. The Has anyone dealt with de aspect is the most important factor.

9 14Dr.LipidDallas, alex_tucson, kevin_tulsa and 6 others
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