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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseHas anyone dealt with de novo lipogenesis reduction on glp-1? Page 6

Has anyone dealt with de novo lipogenesis reduction on glp-1?

NurseLeah_Nash Sat, Aug 23, 2025 at 1:33 AM 34 replies 1,698 viewsPage 6 of 7
PeptideChemSF
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Aug 23, 2025 at 10:03 AM#26

Can confirm — my data shows the same pattern.

32 21steve_okc, dave_SLC, FDA_TrackerJim and 29 others
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Dr.GutHealth
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Aug 23, 2025 at 10:20 AM#27
MarkLI_maint said:
I started my GLP-1 journey in March 2025 at 265 lbs with metabolic syndrome

Gonna push back on this one. Has anyone dealt with de novo is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But cost accessibility is a real barrier. We should be honest about that.

Last edited: Aug 23, 2025 at 3:20 PM
22 16tyler_CSCS, VanRx_Mike, steve_okc and 19 others
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JakeBK_lifts
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Brooklyn, NY
Aug 23, 2025 at 10:37 AM#28

Want to share my personal experience related to Has anyone dealt with de novo since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 271 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 86 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Has anyone dealt aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Last edited: Aug 23, 2025 at 12:37 PM
30 12LabKate, kate.chem, DataDave and 27 others
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nancy_portland
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Aug 23, 2025 at 10:54 AM#29

Saving this for reference. Top-tier content.

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SteveThurs
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Aug 23, 2025 at 11:11 AM#30

PeptideChemSF — that is really helpful context on Has anyone dealt with de. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

13 15TomTeleRx, DoseLogDan, SleepFixSam and 10 others
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