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Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionCreatine kinase elevations on GLP-1 — 12 month update Page 2

Creatine kinase elevations on GLP-1 — 12 month update

SleepFixSam Wed, Jul 9, 2025 at 7:08 PM 7 replies 1,127 viewsPage 2 of 2
patPC_UT
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Nov 2024
Park City, UT
Jul 9, 2025 at 9:58 PM#6

Okay the water retention thing is what scares me. I weigh myself daily (I know, I know) and seeing the scale go UP would honestly send me into a spiral. My brain knows it's water but my anxiety doesn't care.

Anyone have tips for mentally handling that initial scale bump? Or should I just not weigh myself for 2 weeks when I start?

Last edited: Jul 10, 2025 at 2:58 AM
34 23sarah_nash92, FitDadDave, RunnerRach and 31 others
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Dr.SleepRoch
Senior Member
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5,678
Apr 2024
Rochester, MN
Jul 9, 2025 at 10:15 PM#7

Honestly? Don't weigh yourself for 3 weeks when you start creatine. Or switch to weekly weigh-ins using a rolling average. The day-to-day fluctuations on creatine + GLP-1 + normal water/food variation can be like 2-3kg in either direction on any given day. It'll drive you nuts.

Better metrics while on creatine: waist circumference, how clothes fit, progress photos, lifting numbers. The scale becomes a less useful tool (it was never a great one honestly).

28 24kim_atl_prep, sarah_TO, wendy_avl and 25 others
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tony_orlando
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Nov 2024
Orlando, FL
Jul 9, 2025 at 10:32 PM#8

I'll play devil's advocate slightly. While creatine is safe and well-studied, I think the GLP-1 community sometimes treats it as a magic bullet for muscle preservation. It helps, yes, but the effect size is modest. The hierarchy should be:

  1. Adequate protein intake (1.2-1.6g/kg) — biggest impact
  2. Consistent resistance training with progressive overload — second biggest
  3. Adequate sleep (7-9 hrs) — often overlooked, hugely important
  4. Creatine 5g/day — helpful but marginal compared to the above

Don't add creatine while eating 60g protein and doing no exercise. Fix the foundations first.

11 0ZaraB_AL, JakeSmashed95, NauseaFreeNow and 8 others
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VanRx_Mike
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May 2024
Vancouver, CA
Jul 9, 2025 at 10:49 PM#9

Totally fair hierarchy. Creatine is the cherry on top, not the cake itself. Thanks everyone for the thorough discussion — this is exactly the kind of evidence-based conversation I was hoping for. Starting 5g/day tomorrow, no loading phase, with breakfast. Will report back in a month. 💊🏋️

13 17Dr.Martinez, mike_mod, SarahChen_PharmD and 10 others
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