Saving this for reference. Quality thread.

Slightly tangential to BPC-157 systemic vs local but mia_MS2 reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Relevant to BPC-157 systemic vs local — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 229 → 99 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Want to share my personal experience related to BPC-157 systemic vs local since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 285 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 18 months later: I am down 70 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The BPC-157 systemic vs aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

SleepDoc_PDX — that is really helpful context on BPC-157 systemic vs local. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.