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Evidence-based GLP-1 & peptide discussion since 2023
Forumsβ€ΊSide Effects & Managementβ€ΊAnyone else get weird vivid dreams on sema??

Anyone else get weird vivid dreams on sema??

SleepFixSam Mon, Jan 5, 2026 at 1:51 AM 5 replies 590 viewsPage 1 of 1
SleepFixSam
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Hawaii
Jan 5, 2026 at 3:16 AM#1

Can I just vent for a second about anyone else get weird vivid dreams?

I know this forum is evidence-based and I love that about it, but sometimes you just need to let it out. I hit another plateau and I am frustrated.

Not looking for a fix necessarily β€” just solidarity. Anyone else going through this right now?

42 2pete_nash, hank_denver, carlos_SATX and 39 others
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Dr.CardioMD
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Jan 5, 2026 at 3:33 AM#2

SleepFixSam's experience with Anyone else get weird resonates deeply with mine. I went through almost the identical process β€” starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 52 lbs in 7 months.

One thing I would add that SleepFixSam did not mention: the relationship with food fundamentally changed.

Last edited: Jan 5, 2026 at 9:33 AM
24 8Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 21 others
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Dr.RaviCardio
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Jan 5, 2026 at 3:50 AM#3

Thanks for sharing this, SleepFixSam. A few questions about your Anyone else get experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Anyone else get?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Jan 5, 2026 at 4:50 AM
4 24mark_tokyo, hans_munich, jason_sac26 and 1 other
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SleepFixSam
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Nov 2024
Hawaii
Jan 5, 2026 at 4:07 AM#4

OP here β€” wow, did not expect this much response! Thank you all for the thoughtful replies on Anyone else get weird.

To answer Dr.RaviCardio: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion β€” this is exactly why I posted in a science-based community. πŸ™

Last edited: Jan 5, 2026 at 6:07 AM
27 1denise_HTX, raj_cambridge, ingrid_STO and 24 others
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DataDave
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Jan 5, 2026 at 4:24 AM#5

Relevant to Anyone else get weird vivid β€” here is my latest bloodwork comparison:

Key improvements: A1C 7.6% β†’ 5.5%, triglycerides 245 β†’ 115 mg/dL, hsCRP 8.0 β†’ 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Jan 5, 2026 at 5:24 AM
7 15Dr.GutHealth, amsterdam_pete, LondonLisa and 4 others
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