Day 3 on sema and I — I finally have something positive to report and wanted to share.

After 6 months of ups and downs, things are clicking. My latest measurements confirmed what I have been feeling — this is working.

Not trying to brag — I know everyone's journey is different. Just want to put some positive energy out there for anyone who needs it today. ❤️

jason_sac26's experience with Day 3 on sema and I feel resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 58 lbs in 13 months.

One thing I would add that jason_sac26 did not mention: the mental health improvements were just as significant.

Thanks for sharing this, jason_sac26. A few questions about your Day 3 on sema and I experience:

1. What dose did you start at?
2. How long before you noticed side effects improving?
3. Did your provider have any specific recommendations about Day 3 on sema?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Day 3 on sema and I feel.

To answer labquiet_amy: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to Day 3 on sema and I feel like — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 211 → 111 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.