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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementDay 3 on sema and I feel like death warmed over Page 2

Day 3 on sema and I feel like death warmed over

jason_sac26 Wed, Dec 31, 2025 at 9:36 PM 7 replies 741 viewsPage 2 of 2
julia.endo
Senior Member
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Feb 2024
Cincinnati, OH
Jan 1, 2026 at 12:26 AM#6

Congrats jason_sac26!! Keep going — you're doing incredible. 🎉

21 24anna.melb_AU, mark_tokyo, hans_munich and 18 others
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Dr.LeslieOBGYN
Member
567
2,567
May 2024
Dallas, TX
Jan 1, 2026 at 12:43 AM#7

Clinical perspective on Day 3 on sema and I feel like death:

I have managed roughly 300 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

26 22FranDenver, Dr.BariatricHTX, LindaRN_retired and 23 others
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Dr.NateNeph
VIP Member
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Dec 2023
Houston, TX
Jan 1, 2026 at 1:00 AM#8

Can confirm — my data shows the same pattern.

29 2SteveThurs, B12Beth, RickReta_CO and 26 others
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NauseaFreeNow
Member
345
1,234
Aug 2024
Indiana
Jan 1, 2026 at 1:17 AM#9

Reading this thread on Day 3 on sema and I feel hits close to home. Dad of 2 checking in — I started at 265 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 40 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Day 3 on sema and I — take the leap. It was the best health decision I have ever made. ❤️

23 2lori_vegas, Dr.PulmRoch, maya_sedona and 20 others
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A1cHero_PHX
Member
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2,678
Jul 2024
Phoenix, AZ
Jan 1, 2026 at 1:34 AM#10
julia.endo said:
Keep going — you're doing incredible

This is exactly right. julia.endo articulated what I have been trying to explain to my doctor for months. The Day 3 on sema and I feel aspect is the most important factor.

31 14jason_sac26, chris_chi24, tampaLisa73 and 28 others
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