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Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionHIIT vs LISS cardio on GLP-1 — looking for input Page 4

HIIT vs LISS cardio on GLP-1 — looking for input

mark_tokyo Wed, May 21, 2025 at 11:20 AM 39 replies 1,657 viewsPage 4 of 8
mark_tokyo
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Tokyo, JP
May 21, 2025 at 5:00 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on HIIT vs LISS cardio on.

To answer CarlaRPh_TPA: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: May 21, 2025 at 8:00 PM
47 4pete_manc_UK, anna.melb_AU, mark_tokyo and 44 others
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Dr.NateNeph
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May 21, 2025 at 5:17 PM#17

Relevant to HIIT vs LISS cardio on GLP-1 — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 229 → 99 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

28 1NauseaFreeNow, SteveThurs, B12Beth and 25 others
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LindaRN_retired
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May 21, 2025 at 5:34 PM#18

100%. My provider said the same thing about HIIT vs LISS cardio.

16 10amsterdam_pete, LondonLisa, mike_nyc and 13 others
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Dr.GutHealth
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Minnesota
May 21, 2025 at 5:51 PM#19

Slightly tangential to HIIT vs LISS cardio on but tommy_boulder reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

20 10Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 17 others
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hank_denver
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Denver, CO
May 21, 2025 at 6:08 PM#20
mark_tokyo said:
Thank you all for the thoughtful replies on HIIT vs LISS cardio on

This is exactly right. mark_tokyo articulated what I have been trying to explain to my doctor for months. The HIIT vs LISS cardio on aspect is the most important factor.

25 0Dr.DermMIA, fiona_VT, denise_HTX and 22 others
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