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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseHas anyone dealt with what even is mash? my doc mentioned it and i panicked? Page 4

Has anyone dealt with what even is mash? my doc mentioned it and i panicked?

JessicaH_TX Mon, Jun 23, 2025 at 6:36 AM 21 replies 1,461 viewsPage 4 of 5
JessicaH_TX
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Jun 23, 2025 at 12:16 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Has anyone dealt with.

To answer sarah.morrison: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

43 22wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 40 others
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SleepDoc_PDX
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Portland, OR
Jun 23, 2025 at 12:33 PM#17

Relevant to Has anyone dealt with what — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 193 → 93 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Jun 23, 2025 at 3:33 PM
25 8hank_denver, carlos_SATX, sophie_paris and 22 others
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raj_cambridge
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Cambridge, MA
Jun 23, 2025 at 12:50 PM#18

100%. My provider said the same thing about Has anyone dealt.

18 10TomTeleRx, DoseLogDan, SleepFixSam and 15 others
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Dr.ObesityMed
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Jun 23, 2025 at 1:07 PM#19

Slightly tangential to Has anyone dealt with but fiona_VT reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jun 23, 2025 at 7:07 PM
42 14PeptideChemSF, A1cHero_PHX, Dr.RenalNash and 39 others
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SteveThurs
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Jun 23, 2025 at 1:24 PM#20
JessicaH_TX said:
Thank you all for the thoughtful replies on Has anyone dealt with

This is exactly right. JessicaH_TX articulated what I have been trying to explain to my doctor for months. The Has anyone dealt with aspect is the most important factor.

28 10TomTeleRx, DoseLogDan, SleepFixSam and 25 others
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