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ForumsSide Effects & ManagementFatigue on semaglutide — what worked for you? Page 3

Fatigue on semaglutide — what worked for you?

LabKate Thu, Dec 4, 2025 at 5:23 AM 11 replies 963 viewsPage 3 of 3
carlos_SATX
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Oct 2024
San Antonio, TX
Dec 4, 2025 at 9:38 AM#11

NurseLeah_Nash — wow. I've been looking for this exact info for weeks.

10 17james_edin, FranDenver, Dr.BariatricHTX and 7 others
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marcus_mpls
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Nov 2024
Minneapolis, MN
Dec 4, 2025 at 9:55 AM#12

Slightly tangential to Fatigue on semaglutide but LabKate reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

39 18oliver_london, tane_welly, Dr.PathRoch and 36 others
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tommy_boulder
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Nov 2024
Boulder, CO
Dec 4, 2025 at 10:12 AM#13

Thanks for sharing this, LabKate. A few questions about your Fatigue on semagluti experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Fatigue on sema?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Dec 4, 2025 at 11:12 AM
14 16robert_kc, dan_philly, MeganSA_TX and 11 others
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LabKate
Senior Member
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Jan 2024
Oregon
Dec 4, 2025 at 10:29 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Fatigue on semaglutide .

To answer marcus_mpls: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

34 13emily_PDX, Dr.SleepRoch, laura_annarbor and 31 others
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Dr.PeteFamMed
Senior Member
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Jan 2024
Minneapolis, MN
Dec 4, 2025 at 10:46 AM#15

Relevant to Fatigue on semaglutide what — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 203 → 103 mg/dL, hsCRP 6.0 → 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

49 23FranDenver, Dr.BariatricHTX, LindaRN_retired and 46 others
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