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Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionCrossFit on tirzepatide — what worked for you? Page 6

CrossFit on tirzepatide — what worked for you?

labquiet_amy Wed, Apr 16, 2025 at 2:25 AM 49 replies 2,245 viewsPage 6 of 10
jennifer_SEA
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Seattle, WA
Apr 16, 2025 at 10:55 AM#26

Congrats labquiet_amy!! You should be so proud of yourself. 🎉

20 14lucas_SP_BR, lisa_labSD, adam_van and 17 others
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PharmacoVig_BOS
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Boston, MA
Apr 16, 2025 at 11:12 AM#27

Slightly tangential to CrossFit on tirzepatide but Admin reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Apr 16, 2025 at 2:12 PM
41 23Dr.GutHealth, amsterdam_pete, LondonLisa and 38 others
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Dr.RheumBOS
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Apr 16, 2025 at 11:29 AM#28

Yep. My endo said the same thing about CrossFit on.

40 22cory_ATX, lori_vegas, Dr.PulmRoch and 37 others
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carlos_SATX
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San Antonio, TX
Apr 16, 2025 at 11:46 AM#29

Reading this thread on CrossFit on tirzepatide hits close to home. Night shift nurse — I started at 263 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 38 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about CrossFit on — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Apr 16, 2025 at 1:46 PM
32 20LindaRN_retired, tommy_boulder, hyun_seoul and 29 others
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Dr.PulmRoch
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Apr 16, 2025 at 12:03 PM#30

As a pharmacist, I want to add some clinical context to this discussion on CrossFit on tirzepatide what worked for.

Building on what Dr.RheumBOS said — the evidence base here is robust. The key publications to reference are from the FLOW program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
18 21KristenIndy, MarkLI_maint, Dr.PeteFamMed and 15 others
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