OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on TB-500 for the shoulder.

To answer JakeBK_lifts: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Slightly tangential to TB-500 for the shoulder but TrialTracker_MD reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Relevant to TB-500 for the shoulder pain — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 239 → 109 mg/dL, hsCRP 6.0 → 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Want to share my personal experience related to TB-500 for the shoulder pain since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 250 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 80 lbs, my labs have normalized, and I am off 2 of my 3 medications. The TB-500 for the aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

JakeBK_lifts — that is really helpful context on TB-500 for the shoulder. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.