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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementHas anyone dealt with hypoglycemia risk with concomitant sulfonylurea use? Page 2

Has anyone dealt with hypoglycemia risk with concomitant sulfonylurea use?

ChrisMacros Tue, Nov 18, 2025 at 4:58 PM 6 replies 824 viewsPage 2 of 2
Dr.ReproEndo
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Nov 18, 2025 at 7:48 PM#6

Saving this for reference. Quality thread.

37 0mona_PHX, andrew_nyc, Dr.EndoEP and 34 others
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Dr.MetabolicMD
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Nov 18, 2025 at 8:05 PM#7

Slightly tangential to Has anyone dealt with but adam_van reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Nov 18, 2025 at 10:05 PM
28 11PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 25 others
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dave_SLC
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Nov 18, 2025 at 8:22 PM#8

+1 to adam_van. Especially the point about "A few questions about your Has anyone de..." — I have seen the same in my own experience with Has anyone dealt with.

Last edited: Nov 19, 2025 at 12:22 AM
49 8james_edin, FranDenver, Dr.BariatricHTX and 46 others
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fiona_VT
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Nov 18, 2025 at 8:39 PM#9

anders_CPH — that is really helpful context on Has anyone dealt with. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

46 10chris_chi24, tampaLisa73, KarenAZ_mom and 43 others
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pat_auckland
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Auckland, NZ
Nov 18, 2025 at 8:56 PM#10

To answer dave_SLC's question specifically:

From a clinical standpoint, Has anyone dealt with is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

Last edited: Nov 19, 2025 at 12:56 AM
47 23dan_philly, MeganSA_TX, LarryQC_SD and 44 others
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