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ForumsSemaglutide (Ozempic / Wegovy)Drug interactions with semaglutide — May 2025 Page 2

Drug interactions with semaglutide — May 2025

RegAffairsDC Sat, Aug 17, 2024 at 6:51 AM 10 replies 1,760 viewsPage 2 of 2
Dr.EndoEP
Member
267
1,234
Oct 2024
El Paso, TX
Aug 17, 2024 at 9:41 AM#6

For anyone in a physically demanding role:

  • Start your medication on a stretch of days off if possible, so you can gauge your response
  • Don't under-eat. Set a caloric floor (1500+ for active jobs) and hit it even when not hungry
  • Frontload your calories — bigger breakfast before a shift, not a big dinner after
  • Electrolyte packets (LMNT, Liquid IV, etc.) during shifts
  • If fatigue is severe enough to impact patient safety or job performance, that's a conversation with your prescriber about dosing schedule or slower titration

The fatigue is almost always worst in the first 4-6 weeks and improves as your body adapts to both the drug and the new caloric baseline.

17 3NicoleRaleigh, james_edin, FranDenver and 14 others
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LabKate
Senior Member
2,678
11,234
Jan 2024
Oregon
Aug 17, 2024 at 9:58 AM#7

One thing that's helped me enormously: strategic caffeine timing. I have coffee at 7am and green tea at 1pm. Not more, not later. Gives me two energy bumps without wrecking my sleep. And I eat a high-protein snack (Greek yogurt, handful of almonds, string cheese) between meals to prevent energy crashes. Small things but they add up.

23 15laura_annarbor, JenMemphis, pat_auckland and 20 others
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ingrid_STO
Member
345
1,456
Jul 2024
Stockholm, SE
Aug 17, 2024 at 10:15 AM#8

Okay, reality check received. I tracked everything carefully yesterday and I ate... 1,050 calories. I'm basically intermittent starving, not intermittent fasting. Going to make a conscious effort to hit 1,400 minimum starting today and get bloodwork done this week. Thank you all.

Last edited: Aug 17, 2024 at 1:15 PM
14 19MikeFit_NJ, InsuranceTom, WendyG_ATL and 11 others
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