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ForumsCOA & Analytical TestingLC-MS/MS vs HPLC for peptide analysis — which is more reliable? Page 4

LC-MS/MS vs HPLC for peptide analysis — which is more reliable?

HPLC_Greg Sun, Mar 8, 2026 at 8:25 AM 19 replies 492 viewsPage 4 of 4
amy_econ_NJ
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Mar 8, 2026 at 2:05 PM#16

Congrats LipidDoc_ATL!! Keep going — you're doing incredible. 🎉 👏

13 21Dr.SportsMedIN, amy_econ_NJ, bbq_ray_KC and 10 others
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SandraNC_45
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Charlotte, NC
Mar 8, 2026 at 2:22 PM#17

Reading this thread on LC-MS/MS vs HPLC for hits close to home. Night shift nurse — I started at 267 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 42 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about LC-MS/MS vs HPLC for — take the leap. It was the best health decision I have ever made. ❤️

33 14james_edin, FranDenver, Dr.BariatricHTX and 30 others
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pam_stl
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St. Louis, MO
Mar 8, 2026 at 2:39 PM#18

traveltech_sara — that is really helpful context on LC-MS/MS vs HPLC for. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Last edited: Mar 8, 2026 at 7:39 PM
32 2PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 29 others
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AmyNC_wife
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Mar 8, 2026 at 2:56 PM#19

Reading this thread on LC-MS/MS vs HPLC for hits close to home. Dad of 2 checking in — I started at 289 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 64 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about LC-MS/MS vs HPLC for — take the leap. It was the best health decision I have ever made. ❤️

50 0Dr.NateNeph, PharmD_Rodriguez, julia.endo and 47 others
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CanadaChris
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Toronto, CA
Mar 8, 2026 at 3:13 PM#20

AmyNC_wife — that is really helpful context on LC-MS/MS vs HPLC for. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Mar 8, 2026 at 9:13 PM
29 0lori_vegas, Dr.PulmRoch, maya_sedona and 26 others
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