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Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionHas anyone dealt with creatine loading vs maintenance on glp-1? Page 2

Has anyone dealt with creatine loading vs maintenance on glp-1?

LindaRN_retired Wed, Mar 19, 2025 at 6:22 AM 11 replies 1,398 viewsPage 2 of 3
NurseKim_ATL
Senior Member
1,678
7,234
Feb 2024
Atlanta, GA
Mar 19, 2025 at 9:12 AM#6

Okay the water retention thing is what scares me. I weigh myself daily (I know, I know) and seeing the scale go UP would honestly send me into a spiral. My brain knows it's water but my anxiety doesn't care.

Anyone have tips for mentally handling that initial scale bump? Or should I just not weigh myself for 2 weeks when I start?

16 5denise_HTX, raj_cambridge, ingrid_STO and 13 others
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tyler_CSCS
Member
567
2,567
Jun 2024
Phoenix, AZ
Mar 19, 2025 at 9:29 AM#7

Honestly? Don't weigh yourself for 3 weeks when you start creatine. Or switch to weekly weigh-ins using a rolling average. The day-to-day fluctuations on creatine + GLP-1 + normal water/food variation can be like 2-3kg in either direction on any given day. It'll drive you nuts.

Better metrics while on creatine: waist circumference, how clothes fit, progress photos, lifting numbers. The scale becomes a less useful tool (it was never a great one honestly).

Last edited: Mar 19, 2025 at 11:29 AM
47 12hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 44 others
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PeptideSynthNJ
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234
1,234
Aug 2024
Princeton, NJ
Mar 19, 2025 at 9:46 AM#8

I'll play devil's advocate slightly. While creatine is safe and well-studied, I think the GLP-1 community sometimes treats it as a magic bullet for muscle preservation. It helps, yes, but the effect size is modest. The hierarchy should be:

  1. Adequate protein intake (1.2-1.6g/kg) — biggest impact
  2. Consistent resistance training with progressive overload — second biggest
  3. Adequate sleep (7-9 hrs) — often overlooked, hugely important
  4. Creatine 5g/day — helpful but marginal compared to the above

Don't add creatine while eating 60g protein and doing no exercise. Fix the foundations first.

Last edited: Mar 19, 2025 at 1:46 PM
24 6BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 21 others
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AmyNC_wife
Member
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Jun 2024
North Carolina
Mar 19, 2025 at 10:03 AM#9

Totally fair hierarchy. Creatine is the cherry on top, not the cake itself. Thanks everyone for the thorough discussion — this is exactly the kind of evidence-based conversation I was hoping for. Starting 5g/day tomorrow, no loading phase, with breakfast. Will report back in a month. 💊🏋️

31 22Dr.NateNeph, PharmD_Rodriguez, julia.endo and 28 others
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