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ForumsMASH / Liver DiseaseALT normalization rates on GLP-1 — anyone have experience? Page 3

ALT normalization rates on GLP-1 — anyone have experience?

SurmountFan_IN Thu, Apr 24, 2025 at 1:14 PM 11 replies 1,387 viewsPage 3 of 3
nick_newbie
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Apr 24, 2025 at 5:29 PM#11
HPLC_Greg said:
ALT normalization rates on GLP-1 is not that straightforward in my experience

This is exactly right. HPLC_Greg articulated what I have been trying to explain to my doctor for months. The ALT normalization rates aspect is the most important factor.

44 10robert_kc, dan_philly, MeganSA_TX and 41 others
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TrialNerd_Beth
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Apr 24, 2025 at 5:46 PM#12

Reading this thread on ALT normalization rates hits close to home. Night shift nurse — I started at 287 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 62 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about ALT normalization — take the leap. It was the best health decision I have ever made. ❤️

16 4PharmHunterJen, TomTeleRx, DoseLogDan and 13 others
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JakeBK_lifts
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Apr 24, 2025 at 6:03 PM#13

LindaRN_retired — that is really helpful context on ALT normalization rates. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

39 17LabKate, kate.chem, DataDave and 36 others
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PharmD_Rodriguez
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Apr 24, 2025 at 6:20 PM#14

To answer TrialNerd_Beth's question specifically:

From a clinical standpoint, ALT normalization rates on is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

Last edited: Apr 24, 2025 at 11:20 PM
48 17dan_philly, MeganSA_TX, LarryQC_SD and 45 others
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Dr.SportsMedIN
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Apr 24, 2025 at 6:37 PM#15

Bookmarked 📌 The ALT normalization info in this thread is essential. Coming back to this for sure.

Last edited: Apr 24, 2025 at 11:37 PM
40 0rachel_ABQ, traveltech_sara, AttorneyGrant and 37 others
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