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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementHeadaches on GLP-1 — 6 month update

Headaches on GLP-1 — 6 month update

EndoResFellow Sun, Nov 2, 2025 at 1:40 AM 10 replies 856 viewsPage 1 of 2
EndoResFellow
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Sep 2024
Baltimore, MD
Nov 2, 2025 at 3:05 AM#1

My endo and I disagree about headaches on glp-1 6 month update and I want a reality check.

They are saying that I do not need to worry about it but everything I have read here suggests otherwise.

I trust this community's collective knowledge but I also do not want to go against medical advice without good reason. What would you do?

8 2robert_kc, dan_philly, MeganSA_TX and 5 others
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CarlaRPh_TPA
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Jan 2024
Tampa, FL
Nov 2, 2025 at 3:22 AM#2

EndoResFellow's experience with Headaches on GLP-1 6 resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 46 lbs in 11 months.

One thing I would add that EndoResFellow did not mention: the mental health improvements were just as significant.

42 24ricardo_MIA, BrianDallas92, labquiet_amy and 39 others
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ricardo_MIA
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Sep 2024
Miami, FL
Nov 2, 2025 at 3:39 AM#3

Thanks for sharing this, EndoResFellow. A few questions about your Headaches on GLP-1 experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about Headaches on?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

48 23CanadaChris, ZaraB_AL, JakeSmashed95 and 45 others
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EndoResFellow
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Sep 2024
Baltimore, MD
Nov 2, 2025 at 3:56 AM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Headaches on GLP-1 6.

To answer ricardo_MIA: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

34 2NurseKim_ATL, paul_denver, TinaHashiRN and 31 others
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FDA_TrackerJim
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Feb 2024
Rockville, MD
Nov 2, 2025 at 4:13 AM#5

Relevant to Headaches on GLP-1 6 month — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 219 → 119 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Nov 2, 2025 at 7:13 AM
41 3jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 38 others
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