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Evidence-based GLP-1 & peptide discussion since 2023
Forumsβ€ΊProgress & Lab Resultsβ€ΊONE HUNDRED POUNDS DOWN LETS GOOO

ONE HUNDRED POUNDS DOWN LETS GOOO

JakeSmashed95 Thu, Dec 18, 2025 at 6:13 AM 27 replies 1,129 viewsPage 1 of 6
JakeSmashed95
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Dec 18, 2025 at 7:38 AM#1

πŸŽ‰ MILESTONE: ONE HUNDRED POUNDS DOWN LETS GOOO!

I can not believe I am typing this. A year ago I was in a very different place.

Numbers: A1C was 7.5, now 5.0.

Thank you to this community for keeping me sane through the hard parts. You know who you are. πŸ™

24 4Dr.PainCLE, mike_mealprep, NicoleRaleigh and 21 others
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RetaRick_CA
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Dec 18, 2025 at 7:55 AM#2
JakeSmashed95 said:
ONE HUNDRED POUNDS DOWN LETS GOOO

Gonna push back on this one. ONE HUNDRED POUNDS DOWN LETS GOOO is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong β€” the medication works. But adherence is harder than people admit. We should be honest about that.

Last edited: Dec 18, 2025 at 8:55 AM
12 3AmyNC_wife, SkepticalSean, Dr.CardioMD and 9 others
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Dr.SportsMedIN
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Dec 18, 2025 at 8:12 AM#3
JakeSmashed95 said:
ONE HUNDRED POUNDS DOWN LETS GOOO

This is exactly right. JakeSmashed95 articulated what I have been trying to explain to my friends for months. The ONE HUNDRED POUNDS DOWN aspect is what made the difference for me.

2 13adam_van, Dr.SurgeonPGH
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paige_pharma
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Dec 18, 2025 at 8:29 AM#4

Clinical perspective on ONE HUNDRED POUNDS DOWN LETS GOOO:

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows β€” and what I see in practice β€” is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

49 7lisa_labSD, adam_van, Dr.SurgeonPGH and 46 others
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BariatricNurseD
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Dec 18, 2025 at 8:46 AM#5
Dr.SportsMedIN said:
JakeSmashed95 articulated what I have been trying to explain to my friends for months

I respect Dr.SportsMedIN perspective but I think this oversimplifies things a bit. Re: ONE HUNDRED POUNDS DOWN LETS β€” the subgroup analyses show meaningful heterogeneity.

I am not saying Dr.SportsMedIN wrong entirely β€” just that the picture is more nuanced than a blanket statement. The SURMOUNT data specifically shows baseline BMI-dependent responses.

Last edited: Dec 18, 2025 at 1:46 PM
49 14Dr.EndoIndy, tom_AK, josh_phd_bmore and 46 others
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