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Forumsβ€ΊProgress & Lab Resultsβ€ΊFirst month - only lost 6 lbs, is that bad?

First month - only lost 6 lbs, is that bad?

nick_newbie Sat, Dec 13, 2025 at 2:01 PM 3 replies 681 viewsPage 1 of 1
nick_newbie
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Dec 13, 2025 at 3:26 PM#1

First month - only lost 6 lbs, is that bad?

Wanted to share some data with the community since I know we're all about evidence here.

Background: I have been tracking everything meticulously since starting sema 12 months ago. Here's what I have found regarding first month - only lost 6.

I'll post my numbers below and would love to see others share theirs too. The more data points we have, the better we can all make informed decisions.

Fair warning β€” this is a long post. TL;DR at the bottom for those who do not want the full breakdown.

33 11robert_kc, dan_philly, MeganSA_TX and 30 others
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PeptideChemSF
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Dec 13, 2025 at 3:43 PM#2

nick_newbie's experience with First month - only lost 6 resonates deeply with mine. I went through almost the identical process β€” starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 34 lbs in 9 months.

One thing I would add that nick_newbie did not mention: the mental health improvements were just as significant.

11 21dave_SLC, FDA_TrackerJim, ricardo_MIA and 8 others
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pete_RVA
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Dec 13, 2025 at 4:00 PM#3

Thanks for sharing this, nick_newbie. A few questions about your First month - only experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about First month -?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Dec 13, 2025 at 9:00 PM
25 7Admin, Dr.Martinez, mike_mod and 22 others
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nick_newbie
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Dec 13, 2025 at 4:17 PM#4

OP here β€” wow, did not expect this much response! Thank you all for the thoughtful replies on First month - only lost 6.

To answer pete_RVA: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion β€” this is exactly why I posted in a science-based community. πŸ™

Last edited: Dec 13, 2025 at 7:17 PM
32 16LarryQC_SD, wanda_boise, NurseAsh_DET and 29 others
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lisa_labSD
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Dec 13, 2025 at 4:34 PM#5

Relevant to First month - only lost 6 lbs, β€” here is my latest bloodwork comparison:

Key improvements: A1C 7.2% β†’ 5.3%, triglycerides 247 β†’ 117 mg/dL, hsCRP 6.0 β†’ 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

1 10cory_ATX
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