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ForumsSide Effects & ManagementDiarrhea vs constipation on GLP-1 — anyone have experience? Page 2

Diarrhea vs constipation on GLP-1 — anyone have experience?

HPLC_Greg Thu, Oct 9, 2025 at 3:28 AM 21 replies 1,190 viewsPage 2 of 5
anders_CPH
Senior Member
1,567
7,234
Feb 2024
Copenhagen, DK
Oct 9, 2025 at 6:18 AM#6

Glad it resolved. A few additional points for everyone reading this later:

When constipation on GLP-1s requires medical attention:

  • No BM for 7+ days despite OTC interventions
  • Severe abdominal pain or distension
  • Vomiting (could indicate obstruction)
  • Blood in stool or rectal bleeding
  • Fecal impaction symptoms (constant urge, inability to pass, leaking of liquid stool around impaction)

Also — and I say this gently — make sure you're actually eating enough. Some patients get so focused on appetite suppression that they're consuming <800 calories and barely any fiber. Your colon needs bulk to work with. Even on a GLP-1, aim for 20-25g of fiber daily.

32 5CryptoCarl, MariaRD, AussieAnna and 29 others
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TinaHashiRN
Member
345
1,567
Sep 2024
Raleigh, NC
Oct 9, 2025 at 6:35 AM#7

Adding my two cents: a squatty potty (or any footstool that gets your knees above your hips) made a real difference for me. Changes the angle of the anorectal junction. Combined with Miralax it went from "impossible" to "manageable."

Also seconding the walking recommendation. On days I walk 30+ minutes, things move. On days I sit at my desk all day, nothing.

28 16mike_mod, SarahChen_PharmD, sarah.morrison and 25 others
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TrialNerd_Beth
Senior Member
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11,234
Jan 2024
Bethesda, MD
Oct 9, 2025 at 6:52 AM#8

One more underrated tip: warm beverages. Hot coffee in the morning has a well-documented prokinetic effect on the colon. Even if the drug is slowing your GI tract, caffeine and the gastrocolic reflex from warm liquid can help kickstart things. I have a cup of hot coffee within 20 minutes of waking up and it's the most reliable part of my constipation management.

37 3TomTeleRx, DoseLogDan, SleepFixSam and 34 others
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