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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementDiarrhea vs constipation on GLP-1 — anyone have experience? Page 3

Diarrhea vs constipation on GLP-1 — anyone have experience?

HPLC_Greg Thu, Oct 9, 2025 at 3:28 AM 21 replies 1,190 viewsPage 3 of 5
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Oct 9, 2025 at 7:43 AM#11

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

Last edited: Oct 9, 2025 at 11:43 AM
8 11PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 5 others
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Dr.AddMedPHL
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Oct 9, 2025 at 8:00 AM#12

Slightly tangential to Diarrhea vs constipation but RetaRick_CA reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

19 11sarah_nash92, FitDadDave, RunnerRach and 16 others
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matt_MKE
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Oct 9, 2025 at 8:17 AM#13
fiona_glasgow said:
Follow-up question: what labs did your doctor order to monitor this

This is exactly right. fiona_glasgow articulated what I have been trying to explain to my friends for months. The Diarrhea vs constipation aspect is what made the difference for me.

28 14GraceAZ_72, carl_compliance, DanielChem_CHI and 25 others
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quinn_sf
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Oct 9, 2025 at 8:34 AM#14

Saving this for reference. Quality thread.

1 12andrew_nyc
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BiostatsBrad
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Oct 9, 2025 at 8:51 AM#15

Adding my data to this Diarrhea vs constipation discussion:

MetricBaselineMonth 5Month 6
Weight252 lbs237 lbs197 lbs
A1C6.6%6.0%5.2%
hsCRP6.04.01.0

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

Last edited: Oct 9, 2025 at 9:51 AM
40 5NicoleRaleigh, james_edin, FranDenver and 37 others
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