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Evidence-based GLP-1 & peptide discussion since 2023
Forumsβ€ΊProgress & Lab Resultsβ€ΊNot losing weight but my clothes fit different?? Explain

Not losing weight but my clothes fit different?? Explain

SaraMom3 Fri, Nov 28, 2025 at 7:31 PM 11 replies 980 viewsPage 1 of 3
SaraMom3
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Aug 2024
Ohio
Nov 28, 2025 at 8:56 PM#1

Okay I need help with this β€” not losing weight but my clothes.

I have been dealing with this for weeks and I am getting frustrated. Googling just gives me contradictory information and my doctor does not seem to take it seriously.

Please tell me someone here has been through this and come out the other side. What did you do? What finally worked?

I know there are some really knowledgeable people on this forum so I am hoping someone can point me in the right direction. 😩

28 16BethLabQueen, ChrisMacros, KetoKyle and 25 others
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Dr.SurgeonPGH
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Pittsburgh, PA
Nov 28, 2025 at 9:13 PM#2

To answer the question about Not losing weight but my clothes fit different?? Explain β€” in my experience this comes down to a few key factors.

I have been dealing with this for several months now, and what I have found is that individual responses really do vary. That said, the general consensus on Not losing weight but my seems solid.

What specifically worked for me: tracking everything in a spreadsheet. I would suggest SaraMom3 try the same approach and reporting back.

14 15TomTeleRx, DoseLogDan, SleepFixSam and 11 others
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lucas_SP_BR
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SΓ£o Paulo, BR
Nov 28, 2025 at 9:30 PM#3
Dr.SurgeonPGH said:
Explain β€” in my experience this comes down to a few key factors

Completely agree with Dr.SurgeonPGH. I would add that Not losing weight but my also has implications for body composition that sometimes get overlooked in these discussions.

In my case, following a similar approach led to fewer side effects compared to what I was doing before.

2 11zoe_NC, Dr.ObesityLA
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KristenIndy
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May 2024
Indianapolis, IN
Nov 28, 2025 at 9:47 PM#4

Subscribing to this thread. Not losing weight but my is exactly what I've been researching. πŸ™

17 4DataDave, Dr.GutHealth, amsterdam_pete and 14 others
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EndoResFellow
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Sep 2024
Baltimore, MD
Nov 28, 2025 at 10:04 PM#5

As a healthcare provider, I want to add some clinical context to this discussion on Not losing weight but my clothes fit.

Building on what SaraMom3 said β€” the evidence base here is well-established. The key publications to reference are from the FLOW program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
20 15Dr.ObesityLA, NurseKim_ATL, paul_denver and 17 others
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