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Forumsβ€ΊProgress & Lab Resultsβ€ΊDown 50 lbs and nobody at work has said a WORD

Down 50 lbs and nobody at work has said a WORD

gary_naperville Wed, Nov 12, 2025 at 10:08 PM 7 replies 859 viewsPage 1 of 2
gary_naperville
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Oct 2024
Naperville, IL
Nov 12, 2025 at 11:33 PM#1

Hi all, brand new here. My NP just prescribed semaglutide and I have a question about down 50 lbs and nobody at.

Sorry if this has been asked before β€” I did try searching but the amount of information here is overwhelming (in a good way). I am on day 3 and everything is new to me.

Any guidance appreciated. You all seem really knowledgeable and I am glad I found this community.

8 7SleepFixSam, PurityPaulOR, MaxMetOK and 5 others
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Dr.ObesityLA
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Dec 2023
Los Angeles, CA
Nov 12, 2025 at 11:50 PM#2

gary_naperville's experience with Down 50 lbs and nobody at resonates deeply with mine. I went through almost the identical process β€” starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 48 lbs in 13 months.

One thing I would add that gary_naperville did not mention: the relationship with food fundamentally changed.

Last edited: Nov 13, 2025 at 12:50 AM
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mike_nyc
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Nov 13, 2025 at 12:07 AM#3

Thanks for sharing this, gary_naperville. A few questions about your Down 50 lbs and experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about Down 50 lbs and?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

5 6Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 2 others
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gary_naperville
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Oct 2024
Naperville, IL
Nov 13, 2025 at 12:24 AM#4

OP here β€” wow, did not expect this much response! Thank you all for the thoughtful replies on Down 50 lbs and nobody at.

To answer mike_nyc: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion β€” this is exactly why I posted in a science-based community. πŸ™

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quinn_sf
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Jun 2024
San Francisco, CA
Nov 13, 2025 at 12:41 AM#5

Relevant to Down 50 lbs and nobody at work β€” here is my latest bloodwork comparison:

Key improvements: A1C 8.4% β†’ 5.5%, triglycerides 201 β†’ 101 mg/dL, hsCRP 8.0 β†’ 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

23 3Dr.EndoEP, GraceAZ_72, carl_compliance and 20 others
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