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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementDelayed gastric emptying — what worked for you? Page 2

Delayed gastric emptying — what worked for you?

paige_pharma Sat, Aug 30, 2025 at 12:35 PM 11 replies 1,142 viewsPage 2 of 3
anders_CPH
Senior Member
1,567
7,234
Feb 2024
Copenhagen, DK
Aug 30, 2025 at 3:25 PM#6

Glad you're improving. For the community — this situation highlights why surgical patients should be particularly careful. The AGA and ASA have issued guidance that GLP-1 RAs should be held for at least 1 week (semaglutide) to 3 weeks before elective procedures requiring anesthesia, because residual gastroparesis increases aspiration risk during intubation.

If you're on a GLP-1 RA and have an upcoming surgery, tell your anesthesiologist even if your surgeon didn't ask. This is an active patient safety concern.

17 16CryptoCarl, MariaRD, AussieAnna and 14 others
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PharmD_Rodriguez
Senior Member
3,456
14,567
Jan 2024
Miami, FL
Aug 30, 2025 at 3:42 PM#7

This is exactly why I get nervous about these drugs being treated so casually. They're powerful medications that fundamentally alter GI physiology. The vast majority do fine, but the people who don't can end up in serious situations. Informed consent and regular follow-up with a knowledgeable provider are non-negotiable.

48 6TinaHashiRN, robert_kc, dan_philly and 45 others
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carl_compliance
Member
234
1,123
Nov 2024
Raleigh, NC
Aug 30, 2025 at 3:59 PM#8

FINAL UPDATE — 8 weeks post-discontinuation: Repeat gastric emptying study is normal. 8% retention at 4 hours (down from 62%). I'm eating normally again, no nausea, no vomiting. Full reversal.

My endocrinologist and GI doc are discussing whether I could trial a lower dose or a different GLP-1 RA in the future with close monitoring. For now, I'm just grateful my gut is working again. Thank you to everyone who shared their experience — it helped me stay calm during a really scary time.

20 19ricardo_MIA, BrianDallas92, labquiet_amy and 17 others
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