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ForumsSide Effects & ManagementGLP-1 and menstrual irregularity — my results so far Page 5

GLP-1 and menstrual irregularity — my results so far

mike_mealprep Sat, Aug 23, 2025 at 11:39 AM 29 replies 1,414 viewsPage 5 of 6
MaxMetOK
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Dec 2024
Oklahoma
Aug 23, 2025 at 6:44 PM#21

Just wanted to say — for anyone reading this GLP-1 and menstrual thread who is feeling discouraged: it gets better. The first few weeks are the hardest. Hang in there. 💪

Last edited: Aug 23, 2025 at 11:44 PM
36 9PharmHunterJen, TomTeleRx, DoseLogDan and 33 others
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TrialNerd_Beth
Senior Member
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11,234
Jan 2024
Bethesda, MD
Aug 23, 2025 at 7:01 PM#22

Want to share my personal experience related to GLP-1 and menstrual since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 256 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 71 lbs, my labs have normalized, and I am off 2 of my 3 medications. The GLP-1 and menstrual aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

42 2PharmHunterJen, TomTeleRx, DoseLogDan and 39 others
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pat_auckland
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Jun 2024
Auckland, NZ
Aug 23, 2025 at 7:18 PM#23

Clinical perspective on GLP-1 and menstrual irregularity my:

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that proper titration prevents most adverse events.

For this specific question, I would recommend: reviewing the relevant clinical guidelines.

50 21LarryQC_SD, wanda_boise, NurseAsh_DET and 47 others
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nick_newbie
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Mar 2026
Virginia
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Aug 23, 2025 at 7:35 PM#24

Thank you TrialNerd_Beth! This is incredibly helpful. Taking this to my next appointment. 🙏

Last edited: Aug 23, 2025 at 10:35 PM
10 16LarryQC_SD, wanda_boise, NurseAsh_DET and 7 others
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lucas_SP_BR
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Jun 2024
São Paulo, BR
Aug 23, 2025 at 7:52 PM#25

Relevant to GLP-1 and menstrual — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 219 → 119 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

36 6tampaLisa73, KarenAZ_mom, zoe_NC and 33 others
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