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ForumsMASH / Liver DiseaseAlcohol + MASH + GLP-1 — 6 month update

Alcohol + MASH + GLP-1 — 6 month update

matt_MKE Sun, Dec 29, 2024 at 11:39 PM 13 replies 1,673 viewsPage 1 of 3
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matt_MKE
Member
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Sep 2024
Milwaukee, WI
Dec 30, 2024 at 1:04 AM#1

🎉 MILESTONE: Alcohol + MASH + GLP-1 6!

I can not believe I am typing this. 6 months ago I never thought I would be here.

Numbers: Started at 260 lbs, currently at 200 lbs.

Thank you to this community for keeping me sane through the hard parts. You know who you are. 🙏

42 6andrew_nyc, Dr.EndoEP, GraceAZ_72 and 39 others
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TrialNerd_Beth
Senior Member
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11,234
Jan 2024
Bethesda, MD
Dec 30, 2024 at 1:21 AM#2

matt_MKE's experience with Alcohol + MASH + GLP-1 6 resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 44 lbs in 9 months.

One thing I would add that matt_MKE did not mention: the relationship with food fundamentally changed.

Last edited: Dec 30, 2024 at 5:21 AM
23 2PharmHunterJen, TomTeleRx, DoseLogDan and 20 others
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JessicaH_TX
Senior Member
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13,456
Dec 2023
Houston, TX
Dec 30, 2024 at 1:38 AM#3

Thanks for sharing this, matt_MKE. A few questions about your Alcohol + MASH + experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Alcohol + MASH?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

25 1kim_atl_prep, sarah_TO, wendy_avl and 22 others
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matt_MKE
Member
312
1,345
Sep 2024
Milwaukee, WI
Dec 30, 2024 at 1:55 AM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Alcohol + MASH + GLP-1 6.

To answer JessicaH_TX: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Dec 30, 2024 at 4:55 AM
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bri_stats
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May 2024
Seattle, WA
Dec 30, 2024 at 2:12 AM#5

Relevant to Alcohol + MASH + GLP-1 6 — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 197 → 97 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Dec 30, 2024 at 6:12 AM
6 16julia.endo, JessicaM_2024, TomFromTexas and 3 others
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