🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionCan we normalize being the slowest person at the gym — what worked for you? Page 2

Can we normalize being the slowest person at the gym — what worked for you?

SarahChen_PharmD Tue, Nov 5, 2024 at 4:57 PM 48 replies 2,107 viewsPage 2 of 10
WendyG_ATL
Member
1,023
5,678
Apr 2024
Georgia
Nov 5, 2024 at 7:47 PM#6

Dumb question — does semaglutide lower blood pressure directly or is it only from the weight loss?

45 3Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 42 others
Reply Quote Save Share Report
anna.melb_AU
Member
678
2,890
Apr 2024
Melbourne, AU
Nov 5, 2024 at 8:04 PM#7

Not a dumb question at all. The answer is probably both. The SELECT trial showed blood pressure reductions that were somewhat greater than what would be expected from weight loss alone, suggesting a modest direct vascular effect. Proposed mechanisms include improved endothelial function, reduced arterial stiffness, mild natriuresis (sodium excretion), and reduced sympathetic nervous system activity. But the majority of the benefit is weight-loss mediated.

41 18paige_pharma, emma_london, tammy_FL and 38 others
Reply Quote Save Share Report
Dr.PathRoch
Member
456
2,123
Jun 2024
Rochester, MN
Nov 5, 2024 at 8:21 PM#8

I track this stuff: the SELECT trial showed an average systolic reduction of about 3.4 mmHg beyond what weight loss alone would predict. Meaningful at a population level for cardiovascular outcomes, but most of the BP benefit for any individual is going to come from the weight loss itself.

The OP's extra ~6 mmHg beyond the predicted drop fits within that range, especially considering reduced sodium intake (common with reduced food volume) and increased physical activity are likely confounders.

Last edited: Nov 6, 2024 at 2:21 AM
37 6WendyG_ATL, SaraMom3, Dr.MetabolicMD and 34 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

Similar Threads

Resistance training prevents 73% lean mass loss on semaglutide — RCT review11 replies
DEXA scan longitudinal data — 12 months on GLP-1 + lifting18 replies
Zone 2 cardio + GLP-1: synergistic metabolic benefits — evidence18 replies
Creatine kinase elevations on GLP-1 — exercise-induced or concerning?14 replies
Body recomposition protocol: GLP-1 + progressive overload + high protein8 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register