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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementJoint pain improvement vs new joint pain — looking for input Page 2

Joint pain improvement vs new joint pain — looking for input

Dr.PeteFamMed Fri, Aug 1, 2025 at 2:56 PM 16 replies 1,432 viewsPage 2 of 4
Dr.ObesityLA
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Aug 1, 2025 at 5:46 PM#6
PeptideChemSF said:
For Joint pain improvement vs new joint, here is what the evidence says:The clinical trial data (SEL

Gonna push back on this one. Joint pain improvement vs new joint is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

31 19zoe_NC, Dr.ObesityLA, NurseKim_ATL and 28 others
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anders_CPH
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Aug 1, 2025 at 6:03 PM#7

Adding my data to this Joint pain improvement vs discussion:

MetricBaselineMonth 4Month 8
Weight270 lbs235 lbs205 lbs
A1C6.4%6.2%5.4%
hsCRP4.03.01.2

Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

21 19MariaRD, AussieAnna, BethLabQueen and 18 others
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PeptideSynthNJ
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Aug 1, 2025 at 6:20 PM#8

PharmHunterJen — wow. I've been looking for this exact info for weeks.

Last edited: Aug 1, 2025 at 10:20 PM
13 3BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 10 others
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Dr.EndoEP
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Aug 1, 2025 at 6:37 PM#9

Slightly tangential to Joint pain improvement vs but tyler_CSCS reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

4 18Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 1 other
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mike_mod
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Aug 1, 2025 at 6:54 PM#10

Moderator note: This thread has been getting great engagement. Please remember to cite sources when making clinical claims.

No issues to report — carry on. 👍

Last edited: Aug 1, 2025 at 8:54 PM
48 22PurityPaulOR, MaxMetOK, MounjBrad and 45 others
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