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Evidence-based GLP-1 & peptide discussion since 2023
ForumsExercise & Body CompositionCreatine kinase elevations on GLP-1 — looking for input Page 2

Creatine kinase elevations on GLP-1 — looking for input

BethLabQueen Sat, Sep 21, 2024 at 9:08 AM 51 replies 2,621 viewsPage 2 of 11
hannah_MT
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Feb 2026
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Sep 21, 2024 at 11:58 AM#6

Okay the water retention thing is what scares me. I weigh myself daily (I know, I know) and seeing the scale go UP would honestly send me into a spiral. My brain knows it's water but my anxiety doesn't care.

Anyone have tips for mentally handling that initial scale bump? Or should I just not weigh myself for 2 weeks when I start?

44 8nick_newbie, DadBodDave, AmyNC_wife and 41 others
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Dr.LipidDallas
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Dec 2023
Dallas, TX
Sep 21, 2024 at 12:15 PM#7

Honestly? Don't weigh yourself for 3 weeks when you start creatine. Or switch to weekly weigh-ins using a rolling average. The day-to-day fluctuations on creatine + GLP-1 + normal water/food variation can be like 2-3kg in either direction on any given day. It'll drive you nuts.

Better metrics while on creatine: waist circumference, how clothes fit, progress photos, lifting numbers. The scale becomes a less useful tool (it was never a great one honestly).

32 4wei_SG, cory_ATX, lori_vegas and 29 others
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Dr.Martinez
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Sep 21, 2024 at 12:32 PM#8

I'll play devil's advocate slightly. While creatine is safe and well-studied, I think the GLP-1 community sometimes treats it as a magic bullet for muscle preservation. It helps, yes, but the effect size is modest. The hierarchy should be:

  1. Adequate protein intake (1.2-1.6g/kg) — biggest impact
  2. Consistent resistance training with progressive overload — second biggest
  3. Adequate sleep (7-9 hrs) — often overlooked, hugely important
  4. Creatine 5g/day — helpful but marginal compared to the above

Don't add creatine while eating 60g protein and doing no exercise. Fix the foundations first.

30 9rachel_ABQ, traveltech_sara, AttorneyGrant and 27 others
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chris_chi24
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Sep 2024
Chicago, IL
Sep 21, 2024 at 12:49 PM#9

Totally fair hierarchy. Creatine is the cherry on top, not the cake itself. Thanks everyone for the thorough discussion — this is exactly the kind of evidence-based conversation I was hoping for. Starting 5g/day tomorrow, no loading phase, with breakfast. Will report back in a month. 💊🏋️

8 2PurityPaulOR, MaxMetOK, MounjBrad and 5 others
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