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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementAnyone else get weird vivid dreams on sema?? — looking for input

Anyone else get weird vivid dreams on sema?? — looking for input

LeilaHI Thu, May 29, 2025 at 8:19 PM 13 replies 1,432 viewsPage 1 of 3
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LeilaHI
Member
167
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Jan 2025
Honolulu, HI
May 29, 2025 at 9:44 PM#1

Anyone else get weird vivid dreams on sema?? — looking for input

Saw this come across my feed today and thought the community would want to discuss.

Anyone else get weird vivid dreams is something that affects a lot of us here, and the latest information is worth paying attention to. I'll share what I know and hopefully others can fill in the gaps.

Key points as I understand them:

  • This has been evolving over the past few months
  • There are different perspectives on how to approach it
  • The practical implications depend on your specific situation

What are you all hearing from your providers about this? Anyone have direct experience to share?

46 23COA_Karl, MikeFit_NJ, InsuranceTom and 43 others
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SarahChen_PharmD
VIP Member
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Dec 2023
San Diego, CA
May 29, 2025 at 10:01 PM#2

LeilaHI's experience with Anyone else get weird resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 30 lbs in 5 months.

One thing I would add that LeilaHI did not mention: the mental health improvements were just as significant.

10 10NurseKim_ATL, paul_denver, TinaHashiRN and 7 others
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B12Beth
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Oct 2024
Maryland
May 29, 2025 at 10:18 PM#3

Thanks for sharing this, LeilaHI. A few questions about your Anyone else get experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Anyone else get?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

38 13DanielChem_CHI, marco_milano, pam_columbus and 35 others
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LeilaHI
Member
167
789
Jan 2025
Honolulu, HI
May 29, 2025 at 10:35 PM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Anyone else get weird.

To answer B12Beth: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

10 6LondonLisa, mike_nyc, VendorMark and 7 others
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labquiet_amy
Senior Member
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Mar 2024
Cambridge, MA
May 29, 2025 at 10:52 PM#5

Relevant to Anyone else get weird vivid — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 223 → 93 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

27 5pete_manc_UK, anna.melb_AU, mark_tokyo and 24 others
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