TrialNerd_Beth said:

Short answer: the data supports it for most people

I respect TrialNerd_Beth perspective but I think this oversimplifies things a bit. Re: Wedding dress shopping 3 sizes — the effect size varies considerably by population.

I am not saying TrialNerd_Beth wrong entirely — just that the picture is more nuanced than a blanket statement. The SUSTAIN data specifically shows different outcomes in different metabolic phenotypes.

Relevant to Wedding dress shopping 3 sizes — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 199 → 99 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Thank you Dr.SportsMedIN! This is incredibly helpful. Bookmarking for later. 🙏

Slightly tangential to Wedding dress shopping 3 but jason_paloalto reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍