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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsMarathon PR after 80 lbs weight loss — need advice Page 2

Marathon PR after 80 lbs weight loss — need advice

CanadaChris Fri, Aug 1, 2025 at 6:13 AM 7 replies 1,070 viewsPage 2 of 2
MikeFit_NJ
Senior Member
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Apr 2024
New Jersey
Aug 1, 2025 at 9:03 AM#6
NurseKim_ATL said:
I have been dealing with this for several months now, and what I have found is that individual respo

Gonna push back on this one. Marathon PR after 80 lbs weight is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

28 13LeilaHI, marcus_mpls, DeniseRN_TPA and 25 others
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FDA_TrackerJim
Senior Member
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Rockville, MD
Aug 1, 2025 at 9:20 AM#7

Adding my data to this Marathon PR after 80 lbs discussion:

MetricBaselineMonth 5Month 8
Weight274 lbs239 lbs209 lbs
A1C6.8%6.0%5.4%
hsCRP8.04.00.8

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

2 2Admin, Dr.Martinez
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SurmountFan_IN
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May 2024
Indianapolis, IN
Aug 1, 2025 at 9:37 AM#8

SarahChen_PharmD — wow. I've been looking for this exact info for weeks.

22 11traveltech_sara, AttorneyGrant, DebRD_ATL and 19 others
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andrew_nyc
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Apr 2024
New York, NY
Aug 1, 2025 at 9:54 AM#9

Slightly tangential to Marathon PR after 80 lbs but wanda_boise reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

38 7julia.endo, JessicaM_2024, TomFromTexas and 35 others
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mike_mod
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Aug 1, 2025 at 10:11 AM#10

Moderator note: This thread has been getting great engagement. Please remember to cite sources when making clinical claims.

No issues to report — carry on. 👍

13 17PurityPaulOR, MaxMetOK, MounjBrad and 10 others
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