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ForumsSide Effects & ManagementConstipation on GLP-1: pathophysiology and fiber protocol — November 2025 Page 2

Constipation on GLP-1: pathophysiology and fiber protocol — November 2025

NeuroNate Sat, May 3, 2025 at 9:04 PM 9 replies 1,309 viewsPage 2 of 2
Dr.SportsMedIN
Senior Member
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Feb 2024
Indianapolis, IN
May 3, 2025 at 11:54 PM#6

Glad it resolved. A few additional points for everyone reading this later:

When constipation on GLP-1s requires medical attention:

  • No BM for 7+ days despite OTC interventions
  • Severe abdominal pain or distension
  • Vomiting (could indicate obstruction)
  • Blood in stool or rectal bleeding
  • Fecal impaction symptoms (constant urge, inability to pass, leaking of liquid stool around impaction)

Also — and I say this gently — make sure you're actually eating enough. Some patients get so focused on appetite suppression that they're consuming <800 calories and barely any fiber. Your colon needs bulk to work with. Even on a GLP-1, aim for 20-25g of fiber daily.

21 23lucas_SP_BR, lisa_labSD, adam_van and 18 others
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LeilaHI
Member
167
789
Jan 2025
Honolulu, HI
May 4, 2025 at 12:11 AM#7

Adding my two cents: a squatty potty (or any footstool that gets your knees above your hips) made a real difference for me. Changes the angle of the anorectal junction. Combined with Miralax it went from "impossible" to "manageable."

Also seconding the walking recommendation. On days I walk 30+ minutes, things move. On days I sit at my desk all day, nothing.

Last edited: May 4, 2025 at 5:11 AM
35 13VendorMark, COA_Karl, MikeFit_NJ and 32 others
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DanielChem_CHI
Senior Member
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5,678
Mar 2024
Chicago, IL
May 4, 2025 at 12:28 AM#8

One more underrated tip: warm beverages. Hot coffee in the morning has a well-documented prokinetic effect on the colon. Even if the drug is slowing your GI tract, caffeine and the gastrocolic reflex from warm liquid can help kickstart things. I have a cup of hot coffee within 20 minutes of waking up and it's the most reliable part of my constipation management.

Last edited: May 4, 2025 at 2:28 AM
31 15patPC_UT, Dr.DermMIA, fiona_VT and 28 others
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