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ForumsMASH / Liver DiseaseLiver biopsy changes on semaglutide — looking for input Page 5

Liver biopsy changes on semaglutide — looking for input

Dr.GutHealth Wed, Jul 24, 2024 at 8:18 AM 29 replies 2,184 viewsPage 5 of 6
paul_denver
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Jul 24, 2024 at 3:23 PM#21

pete_RVA — that is really helpful context on Liver biopsy changes on. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Last edited: Jul 24, 2024 at 9:23 PM
8 15Dr.LeslieOBGYN, MikeNYC_runner and 5 others
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Dr.LipidDallas
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Jul 24, 2024 at 3:40 PM#22

To answer julia.endo's question specifically:

From a clinical standpoint, Liver biopsy changes on is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

45 18wei_SG, cory_ATX, lori_vegas and 42 others
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fiona_glasgow
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Jul 24, 2024 at 3:57 PM#23

Thank you paul_denver! This is incredibly helpful. Bookmarking for later. 🙏

Last edited: Jul 24, 2024 at 8:57 PM
39 22KevinCompounds, TirzTom, TrialTracker_MD and 36 others
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Dr.NateNeph
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Jul 24, 2024 at 4:14 PM#24

Relevant to Liver biopsy changes on — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 237 → 107 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

43 9B12Beth, RickReta_CO, PharmHunterJen and 40 others
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TrialTracker_MD
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Jul 24, 2024 at 4:31 PM#25

Slightly tangential to Liver biopsy changes on but paul_denver reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jul 24, 2024 at 9:31 PM
38 10lori_vegas, Dr.PulmRoch, maya_sedona and 35 others
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