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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementHas anyone dealt with fatigue on semaglutide? Page 2

Has anyone dealt with fatigue on semaglutide?

KetoKyle Fri, Mar 28, 2025 at 12:15 PM 6 replies 1,382 viewsPage 2 of 2
Dr.SleepRoch
Senior Member
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Apr 2024
Rochester, MN
Mar 28, 2025 at 3:05 PM#6

For anyone in a physically demanding role:

  • Start your medication on a stretch of days off if possible, so you can gauge your response
  • Don't under-eat. Set a caloric floor (1500+ for active jobs) and hit it even when not hungry
  • Frontload your calories — bigger breakfast before a shift, not a big dinner after
  • Electrolyte packets (LMNT, Liquid IV, etc.) during shifts
  • If fatigue is severe enough to impact patient safety or job performance, that's a conversation with your prescriber about dosing schedule or slower titration

The fatigue is almost always worst in the first 4-6 weeks and improves as your body adapts to both the drug and the new caloric baseline.

14 14sarah_TO, wendy_avl, jason_paloalto and 11 others
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labquiet_amy
Senior Member
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6,789
Mar 2024
Cambridge, MA
Mar 28, 2025 at 3:22 PM#7

One thing that's helped me enormously: strategic caffeine timing. I have coffee at 7am and green tea at 1pm. Not more, not later. Gives me two energy bumps without wrecking my sleep. And I eat a high-protein snack (Greek yogurt, handful of almonds, string cheese) between meals to prevent energy crashes. Small things but they add up.

Last edited: Mar 28, 2025 at 5:22 PM
47 24HPLC_Greg, LibrarianMeg, bri_stats and 44 others
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mike.trainer_LA
Senior Member
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Apr 2024
Los Angeles, CA
Mar 28, 2025 at 3:39 PM#8

Okay, reality check received. I tracked everything carefully yesterday and I ate... 1,050 calories. I'm basically intermittent starving, not intermittent fasting. Going to make a conscious effort to hit 1,400 minimum starting today and get bloodwork done this week. Thank you all.

41 1mia_MS2, LeilaHI, marcus_mpls and 38 others
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