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ForumsSide Effects & ManagementInjection site reactions — looking for input Page 2

Injection site reactions — looking for input

RickReta_CO Wed, Mar 19, 2025 at 2:35 AM 16 replies 1,570 viewsPage 2 of 4
PharmD_Rodriguez
Senior Member
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Jan 2024
Miami, FL
Mar 19, 2025 at 5:25 AM#6

UPDATE — tried warming + icing:

Took the pen out 30 min early, iced the spot for 3 min before, injected slowly (held 10 seconds), iced for 5 min after, didn't rub.

Result: still got a small lump but it's maybe 60% smaller than usual and the redness cleared by day 2 instead of day 5. HUGE improvement!! Going to keep doing this. Thank you all so much 🙏

32 15paul_denver, TinaHashiRN, robert_kc and 29 others
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VanRx_Mike
Member
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May 2024
Vancouver, CA
Mar 19, 2025 at 5:42 AM#7

Glad that helped! The warming is probably the single biggest factor. That medication is viscous when cold and creates more tissue disruption on injection. Most patients who implement the warming step alone see significant improvement.

10 15MikeNYC_runner and 7 others
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PedsEndoPhilly
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Jun 2024
Philadelphia, PA
Mar 19, 2025 at 5:59 AM#8

Great improvement Laura! If the smaller lumps still bother you, a thin layer of OTC hydrocortisone cream on the injection site after the post-injection icing can help with the residual inflammation. Just don't apply it BEFORE injection — you want the area clean and dry pre-injection. 👩‍⚕️

43 22jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 40 others
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