🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementGLP-1 and gastroparesis — need advice Page 2

GLP-1 and gastroparesis — need advice

MounjBrad Sun, Mar 9, 2025 at 1:56 PM 38 replies 1,891 viewsPage 2 of 8
Dr.CardioMD
VIP Member
2,678
14,567
Dec 2023
Cleveland, OH
Mar 9, 2025 at 4:46 PM#6

Glad you're improving. For the community — this situation highlights why surgical patients should be particularly careful. The AGA and ASA have issued guidance that GLP-1 RAs should be held for at least 1 week (semaglutide) to 3 weeks before elective procedures requiring anesthesia, because residual gastroparesis increases aspiration risk during intubation.

If you're on a GLP-1 RA and have an upcoming surgery, tell your anesthesiologist even if your surgeon didn't ask. This is an active patient safety concern.

8 6kim_atl_prep, sarah_TO, wendy_avl and 5 others
Reply Quote Save Share Report
tyler_CSCS
Member
567
2,567
Jun 2024
Phoenix, AZ
Mar 9, 2025 at 5:03 PM#7

This is exactly why I get nervous about these drugs being treated so casually. They're powerful medications that fundamentally alter GI physiology. The vast majority do fine, but the people who don't can end up in serious situations. Informed consent and regular follow-up with a knowledgeable provider are non-negotiable.

Last edited: Mar 9, 2025 at 7:03 PM
41 22hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 38 others
Reply Quote Save Share Report
HealthEcon_DC
Member
567
3,456
Apr 2024
Washington, DC
Mar 9, 2025 at 5:20 PM#8

FINAL UPDATE — 8 weeks post-discontinuation: Repeat gastric emptying study is normal. 8% retention at 4 hours (down from 62%). I'm eating normally again, no nausea, no vomiting. Full reversal.

My endocrinologist and GI doc are discussing whether I could trial a lower dose or a different GLP-1 RA in the future with close monitoring. For now, I'm just grateful my gut is working again. Thank you to everyone who shared their experience — it helped me stay calm during a really scary time.

Last edited: Mar 9, 2025 at 7:20 PM
39 2KevinCompounds, TirzTom, TrialTracker_MD and 36 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results

Similar Threads

Nausea incidence by dose tier — STEP and SURMOUNT meta-analysis16 replies
Constipation on GLP-1: pathophysiology and fiber protocol5 replies
Alopecia on GLP-1 — telogen effluvium differential diagnosis3 replies
Gallbladder disease risk — cholelithiasis data from clinical trials12 replies
Pancreatitis risk assessment — pooled safety analysis15 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register