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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMASH / Liver DiseaseFibrosis regression on GLP-1 — anyone have experience?

Fibrosis regression on GLP-1 — anyone have experience?

PeptideChemSF Thu, May 9, 2024 at 9:25 PM 10 replies 1,943 viewsPage 1 of 2
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PeptideChemSF
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May 9, 2024 at 10:50 PM#1

🎉 MILESTONE: Fibrosis regression on GLP-1 anyone have!

I can not believe I am typing this. 6 months ago I never thought I would be here.

Numbers: Started at 260 lbs, currently at 200 lbs.

Thank you to this community for keeping me sane through the hard parts. You know who you are. 🙏

13 12steve_okc, dave_SLC, FDA_TrackerJim and 10 others
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KevinCompounds
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May 9, 2024 at 11:07 PM#2

PeptideChemSF's experience with Fibrosis regression on resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 58 lbs in 13 months.

One thing I would add that PeptideChemSF did not mention: the mental health improvements were just as significant.

Last edited: May 10, 2024 at 1:07 AM
21 24Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 18 others
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pete_nash
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Nashville, TN
May 9, 2024 at 11:24 PM#3

Thanks for sharing this, PeptideChemSF. A few questions about your Fibrosis regression experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Fibrosis regres?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

42 18mike_mod, SarahChen_PharmD, sarah.morrison and 39 others
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PeptideChemSF
Senior Member
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Jan 2024
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May 9, 2024 at 11:41 PM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Fibrosis regression on.

To answer pete_nash: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: May 10, 2024 at 3:41 AM
4 15ricardo_MIA, BrianDallas92, labquiet_amy and 1 other
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stefan_berlin
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May 9, 2024 at 11:58 PM#5

Relevant to Fibrosis regression on GLP-1 — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 191 → 91 mg/dL, hsCRP 6.0 → 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

33 7TrialTracker_MD, JennaRN, LabKate and 30 others
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