Putting together a summary on size 28 to size 8 need since I keep seeing the same questions pop up.

I am not a medical professional (just a well-researched patient) so take this with appropriate salt, but I have compiled info from this forum and my own experience.

Happy to be corrected by the actual clinicians here — that is the whole point of posting it.

traveltech_sara's experience with Size 28 to size 8 need resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 42 lbs in 7 months.

One thing I would add that traveltech_sara did not mention: the mental health improvements were just as significant.

Thanks for sharing this, traveltech_sara. A few questions about your Size 28 to size 8 experience:

1. What dose worked best for you?
2. How long before you noticed appetite suppression kicking in?
3. Did your endo have any specific recommendations about Size 28 to size?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Size 28 to size 8 need.

To answer kim_atl_prep: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to Size 28 to size 8 need advice — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 215 → 115 mg/dL, hsCRP 6.0 → 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.