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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsNot losing weight but my clothes fit different?? Explain — September 2026

Not losing weight but my clothes fit different?? Explain — September 2026

Dr.NephBHM_UK Sun, Dec 8, 2024 at 8:57 PM 8 replies 1,529 viewsPage 1 of 2
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Dr.NephBHM_UK
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Birmingham, UK
Dec 8, 2024 at 10:22 PM#1

Hi all, brand new here. My doctor just prescribed semaglutide and I have a question about not losing weight but my clothes.

Sorry if this has been asked before — I did try searching but the amount of information here is overwhelming (in a good way). I am on week 2 and everything is new to me.

Any guidance appreciated. You all seem really knowledgeable and I am glad I found this community.

9 9Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 6 others
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BariatricNurseD
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Dec 8, 2024 at 10:39 PM#2

To answer the question about Not losing weight but my clothes fit different?? Explain September 2026 — in my experience this comes down to a few key factors.

I have been dealing with this for several months now, and what I have found is that individual responses really do vary. That said, the general consensus on Not losing weight but my seems solid.

What specifically worked for me: tracking everything in a spreadsheet. I would suggest Dr.NephBHM_UK try the same approach and reporting back.

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TinaHashiRN
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Dec 8, 2024 at 10:56 PM#3
BariatricNurseD said:
Explain September 2026 — in my experience this comes down to a few key factors

Completely agree with BariatricNurseD. I would add that Not losing weight but my also has implications for body composition that sometimes get overlooked in these discussions.

In my case, following a similar approach led to fewer side effects compared to what I was doing before.

Last edited: Dec 9, 2024 at 4:56 AM
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DeniseRN_TPA
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Dec 8, 2024 at 11:13 PM#4

Subscribing to this thread. Not losing weight but my is exactly what I've been researching. 🙏

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Dr.Martinez
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Dec 8, 2024 at 11:30 PM#5

As a healthcare provider, I want to add some clinical context to this discussion on Not losing weight but my clothes fit.

Building on what Dr.NephBHM_UK said — the evidence base here is well-established. The key publications to reference are from the STEP program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
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