Subscribing to this thread. I literally cannot eat is exactly what I've been researching. 🙏

As a pharmacist, I want to add some clinical context to this discussion on I literally cannot eat more than 3 bites.

Building on what josh_phd_bmore said — the evidence base here is robust. The key publications to reference are from the SURMOUNT program[1].

Key clinical points:

1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
2. Side effect profile is predictable and usually manageable with standard protocols
3. Monitoring should include baseline labs and follow-up at 3-month intervals
4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

Reading this thread on I literally cannot eat hits close to home. Dad of 2 checking in — I started at 297 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 72 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about I literally cannot — take the leap. It was the best health decision I have ever made. ❤️

pete_nash — that is really helpful context on I literally cannot eat. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

To answer cory_ATX's question specifically:

From a clinical standpoint, I literally cannot eat more is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.