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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementHas anyone dealt with tmi but the constipation is real? Page 2

Has anyone dealt with tmi but the constipation is real?

carlos_SATX Thu, Jul 11, 2024 at 12:03 PM 8 replies 1,730 viewsPage 2 of 2
Dr.GutHealth
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Jul 11, 2024 at 2:53 PM#6

Glad it resolved. A few additional points for everyone reading this later:

When constipation on GLP-1s requires medical attention:

  • No BM for 7+ days despite OTC interventions
  • Severe abdominal pain or distension
  • Vomiting (could indicate obstruction)
  • Blood in stool or rectal bleeding
  • Fecal impaction symptoms (constant urge, inability to pass, leaking of liquid stool around impaction)

Also — and I say this gently — make sure you're actually eating enough. Some patients get so focused on appetite suppression that they're consuming <800 calories and barely any fiber. Your colon needs bulk to work with. Even on a GLP-1, aim for 20-25g of fiber daily.

20 11VanRx_Mike, steve_okc, dave_SLC and 17 others
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VendorMark
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Jul 11, 2024 at 3:10 PM#7

Adding my two cents: a squatty potty (or any footstool that gets your knees above your hips) made a real difference for me. Changes the angle of the anorectal junction. Combined with Miralax it went from "impossible" to "manageable."

Also seconding the walking recommendation. On days I walk 30+ minutes, things move. On days I sit at my desk all day, nothing.

27 18KristenIndy, MarkLI_maint, Dr.PeteFamMed and 24 others
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Dr.CardioMD
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Jul 11, 2024 at 3:27 PM#8

One more underrated tip: warm beverages. Hot coffee in the morning has a well-documented prokinetic effect on the colon. Even if the drug is slowing your GI tract, caffeine and the gastrocolic reflex from warm liquid can help kickstart things. I have a cup of hot coffee within 20 minutes of waking up and it's the most reliable part of my constipation management.

47 12tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 44 others
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