To answer RegAffairsDC's question specifically:

From a clinical standpoint, Nausea incidence by dose tier is something I discuss with patients regularly.

The short answer: discuss this specific situation with your prescribing provider.

The longer answer involves weighing the risk-benefit ratio for your individual situation, which I am happy to elaborate on if helpful.

Slightly tangential to Nausea incidence by dose but RegAffairsDC reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Nausea incidence by dose.

To answer MikeFit_NJ: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Reading this thread on Nausea incidence by dose hits close to home. Night shift nurse — I started at 283 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 58 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Nausea incidence by — take the leap. It was the best health decision I have ever made. ❤️

Adding my data to this Nausea incidence by dose discussion:

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.