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ForumsSide Effects & ManagementGLP-1 and gastroparesis — what worked for you? Page 2

GLP-1 and gastroparesis — what worked for you?

PeptideSynthNJ Mon, Jan 22, 2024 at 5:47 PM 13 replies 2,009 viewsPage 2 of 3
carl_compliance
Member
234
1,123
Nov 2024
Raleigh, NC
Jan 22, 2024 at 8:37 PM#6

Glad you're improving. For the community — this situation highlights why surgical patients should be particularly careful. The AGA and ASA have issued guidance that GLP-1 RAs should be held for at least 1 week (semaglutide) to 3 weeks before elective procedures requiring anesthesia, because residual gastroparesis increases aspiration risk during intubation.

If you're on a GLP-1 RA and have an upcoming surgery, tell your anesthesiologist even if your surgeon didn't ask. This is an active patient safety concern.

Last edited: Jan 22, 2024 at 11:37 PM
34 23labquiet_amy, emily_PDX, Dr.SleepRoch and 31 others
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Dr.SurgeonPGH
Senior Member
1,345
6,789
Mar 2024
Pittsburgh, PA
Jan 22, 2024 at 8:54 PM#7

This is exactly why I get nervous about these drugs being treated so casually. They're powerful medications that fundamentally alter GI physiology. The vast majority do fine, but the people who don't can end up in serious situations. Informed consent and regular follow-up with a knowledgeable provider are non-negotiable.

41 10TomTeleRx, DoseLogDan, SleepFixSam and 38 others
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wei_SG
Member
234
890
Nov 2024
Singapore, SG
Jan 22, 2024 at 9:11 PM#8

FINAL UPDATE — 8 weeks post-discontinuation: Repeat gastric emptying study is normal. 8% retention at 4 hours (down from 62%). I'm eating normally again, no nausea, no vomiting. Full reversal.

My endocrinologist and GI doc are discussing whether I could trial a lower dose or a different GLP-1 RA in the future with close monitoring. For now, I'm just grateful my gut is working again. Thank you to everyone who shared their experience — it helped me stay calm during a really scary time.

24 15Dr.MetabolicMD, RetaRick_CA, JenPlateau and 21 others
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