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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingHPLC vs UPLC for peptide purity — 6 month update Page 3

HPLC vs UPLC for peptide purity — 6 month update

labquiet_amy Sat, Aug 17, 2024 at 6:30 AM 15 replies 1,855 viewsPage 3 of 3
adam_van
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Nov 2024
Vancouver, CA
Aug 17, 2024 at 10:45 AM#11

DataDave — wow. I've been looking for this exact info for weeks.

12 15FranDenver, Dr.BariatricHTX, LindaRN_retired and 9 others
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wanda_boise
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Aug 2024
Boise, ID
Aug 17, 2024 at 11:02 AM#12

Slightly tangential to HPLC vs UPLC for peptide but labquiet_amy reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

48 23marco_milano, pam_columbus, nick_SD_fit and 45 others
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SleepDoc_PDX
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Sep 2024
Portland, OR
Aug 17, 2024 at 11:19 AM#13

Thanks for sharing this, labquiet_amy. A few questions about your HPLC vs UPLC for experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about HPLC vs UPLC?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

17 2carlos_SATX, sophie_paris, mel_PDX and 14 others
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labquiet_amy
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Mar 2024
Cambridge, MA
Aug 17, 2024 at 11:36 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on HPLC vs UPLC for peptide.

To answer wanda_boise: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

4 21bri_stats, pete_manc_UK, anna.melb_AU and 1 other
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Dr.NateNeph
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Houston, TX
Aug 17, 2024 at 11:53 AM#15

Relevant to HPLC vs UPLC for peptide — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 199 → 99 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

32 22RickReta_CO, PharmHunterJen, TomTeleRx and 29 others
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