🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingLC-MS/MS vs HPLC for peptide analysis — November 2025 Page 8

LC-MS/MS vs HPLC for peptide analysis — November 2025

Dr.SportsMedIN Fri, Apr 26, 2024 at 3:37 PM 51 replies 2,260 viewsPage 8 of 11
AttorneyGrant
Member
567
2,890
Apr 2024
Washington, DC
Apr 27, 2024 at 2:57 AM#36

Slightly tangential to LC-MS/MS vs HPLC for but COA_Karl reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

44 20Dr.SleepRoch, laura_annarbor, JenMemphis and 41 others
Reply Quote Save Share Report
oliver_london
Member
312
1,345
Aug 2024
London, UK
Apr 27, 2024 at 3:14 AM#37

Saving this for reference. Top-tier content.

35 19MikeNYC_runner and 32 others
Reply Quote Save Share Report
tom_AK
New Member
28
112
Jan 2026
Anchorage, AK
Apr 27, 2024 at 3:31 AM#38

Want to share my personal experience related to LC-MS/MS vs HPLC for peptide since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 264 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 18 months later: I am down 79 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The LC-MS/MS vs HPLC for aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

21 20tyler_CSCS, VanRx_Mike, steve_okc and 18 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides
josh_phd_bmore
Member
389
1,678
Jul 2024
Baltimore, MD
Apr 27, 2024 at 3:48 AM#39

Relevant to LC-MS/MS vs HPLC for peptide — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 195 → 95 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

24 7KarenAZ_mom, zoe_NC, Dr.ObesityLA and 21 others
Reply Quote Save Share Report
Dr.CardioMD
VIP Member
2,678
14,567
Dec 2023
Cleveland, OH
Apr 27, 2024 at 4:05 AM#40

Want to share my personal experience related to LC-MS/MS vs HPLC for peptide since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 281 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 10 months later: I am down 86 lbs, my labs have normalized, and I am off 2 of my 3 medications. The LC-MS/MS vs HPLC for aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Last edited: Apr 27, 2024 at 10:05 AM
4 12josh_phd_bmore, roxy_nash, tony_orlando and 1 other
Reply Quote Save Share Report

Similar Threads

HPLC vs UPLC for peptide purity — method comparison study18 replies
Mass spectrometry for peptide identity verification — ESI-MS guide7 replies
Endotoxin testing methods — LAL vs recombinant Factor C17 replies
Red flags on COAs — how to spot a fake certificate5 replies
USP reference standards for peptide verification — sourcing guide3 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register